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Christina Applegate Reveals She Was Misdiagnosed With MS: ‘I’m Back at Square One’ and It’s a ‘Mindf—’

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Christina Applegate Reveals She Was Misdiagnosed With MS: ‘I’m Back at Square One’ and It’s a ‘Mindf—’
Oct 20, 2026 4:53am PT Christina Applegate Reveals She Was Misdiagnosed With MS: ‘I’m Back at Square One’ and It’s a ‘Mindf—’

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Ellise Shafer

See All Add us as a Google Preferred Source LOS ANGELES, CALIFORNIA - FEBRUARY 26: Christina Applegate attends the 29th Annual Screen Actors Guild Awards at Fairmont Century Plaza on February 26, 2023 in Los Angeles, California. (Photo by Frazer Harrison/Getty Images) Frazer Harrison

Christina Applegate returned to her podcast, “MeSsy,” on Tuesday with some shocking news: She was misdiagnosed with multiple sclerosis.

After taking a break from the podcast for seven months due to her health, Applegate tearfully shared the revelation, recalling that her doctor “came into my room and said, ‘Congratulations, you don’t have MS'” (via People). “I was, like, not happy at all,” Applegate continued. “Everybody else was so happy.”

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